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KMID : 0043320140370091219
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Archives of Pharmacal Research
2014 Volume.37 No. 9 p.1219 ~ p.1233
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Quercetin-3-O-β-d-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells
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Yang Hyo-Hyun
Zheng Ming Shan
Hwangbo Kyoung
Zheng Ming Shan
Cho Jung-Hee
Son Jong-Keun
Kim Hwa-Young
Baek Suk-Hwan
Choi Hyung-Chul
Park So-Young
Kim Jae-Ryong
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Abstract
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Cellular senescence is known to contribute to tissue aging, a variety of age-related diseases, tissue regeneration, and cancer. Therefore, aging intervention might be useful for prevention of aging as well as age-related disease. In this study, we investigated compounds from Polygonum aviculare to determine if they inhibited cellular senescence in human primary cells, human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Ten compounds from P. aviculare were purified and their inhibitory effects on adriamycin-induced cellular senescence were measured by observing senescence-associated β-galactosidase (SA-β-gal) activity and reactive oxygen species. Among them, compound 9 (quercetin-3-O-β-d-glucuronide) showed inhibitory effects against cellular senescence in HDFs and HUVECs treated with adriamycin. Additionally, compound 9 rescued replicative senescence in HDFs and HUVECs. These data imply that compound 9 represses cellular senescence in human primary cells and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or aging-associated diseases.
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KEYWORD
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Polygonum aviculare, Cellular senescence, Quercetin-3-O-β-d-glucuronide, Human primary cells, Aging intervention
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